Fig. 6
From: Arterial stiffness and vascular aging: mechanisms, prevention, and therapy

Effects of arterial stiffness on peripheral end organs and clinical manifestations. Arterial stiffening tends to create a vicious cycle in each organ. EPVS enlarged perivascular space, CSVD cerebral small vessel disease, HFpEF heart failure with preserved ejection fraction, MASLD metabolic dysfunction-associated steatotic liver disease, PWV, pulse wave velocity, PAD peripheral artery disease. Created with BioRender.com