Fig. 2

Immune cells in the microenvironment of SCLC. a Analysis of macrophages (Mφs)/monocytes. A total of 7 Mφ subtypes, 2 monocyte subtypes and 1 dendritic cell subtype were identified (left panel). The distribution of cells across different sample types is shown in the right panel. b Dot plot of selected gene expression in each cell lineage. Dot size and color indicate the fraction of expressing cells and normalized expression levels, respectively. c-e Boxplots representing the relative proportions of each Mφ/monocyte population. Comparisons were made among different stages classified by TNM stage (c), smoking status (d), and outcomes of neoadjuvant therapy (e). f Analysis of T/NK cells. A total of 14 subtypes of T/NK cells were identified (left panel). The distribution of cells in different sample types is shown in the right panel. g Boxplots representing the relative proportions of each T/NK cell subtype. Comparisons were made among different stages and outcomes of neoadjuvant therapy. h Analysis of B cells. A total of 9 subtypes of B cells were identified (left panel). The distribution of cells across different sample types is shown in the right panel. i Boxplots representing the relative proportions of each B cell subtype. Comparisons were made among different stages and outcomes of neoadjuvant therapy. P values in (c, d, e, g, and i) were determined via the Wilcoxon rank-sum test. *P < 0.05, **P < 0.01