Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Characterization of the extrinsic and intrinsic signatures and therapeutic vulnerability of small cell lung cancers

Fig. 3The alternative text for this image may have been generated using AI.

Cancer cells and cancer stem-like cells in SCLC. a Analysis of cancer cells and nonimmune normal cells identified 19 cell clusters (left panel). The distribution of cells in different sample types is shown in the right panel. b, c Expression of feature genes in the cell clusters. The expression of ASCL1, NEUROD1, YAP1, and POU2F3 is shown in a violin plot (b). The marker genes of each cluster are shown in dot plots (c). Dot size and color indicate the fraction of expressing cells and normalized expression levels, respectively. d Relative fractions of tumor samples in the 14 cancer cell clusters. e Distribution of distinct tumor cell clusters across the 39 tumor samples. f Gene set enrichment analysis (GSEA) plots for the indicated gene sets in the stem-like cell cluster and the other cancer cell cluster. g Potency and differentiation states of the 19 cell clusters evaluated by the CytoTrace algorithm. h Enrichment scores of potential cell origins for SCLC in lung tissues. The top 100 genes in neuroendocrine, club, ciliated, basal, AT1, and AT2 cells were used for enrichment analysis. i, j Comparisons of the indicated cell clusters at different stages (i) and outcomes of neoadjuvant therapy (j). P values in panels h and i were determined via the Wilcoxon rank-sum test. *P < 0.05; **P < 0.01

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