Fig. 7 | Signal Transduction and Targeted Therapy

Fig. 7

From: Condensate nanovaccine adjuvants augment CD8+ T-Cell-dependent antitumor immunity through mtDNA leakage-triggered cGAS-STING axis activation

Fig. 7The alternative text for this image may have been generated using AI.

Schematic illustration of the mechanism of DC maturation induced by synthetic PCD: the PCD vaccine is partially associated with mitochondria, altering mitochondrial membrane permeability and inducing the release of mitochondrial DNA (mtDNA) into the cytosol. The released mtDNA is recognized by the cytoplasmic enzyme cyclic GMP-AMP synthase (cGAS), leading to the production of cyclic GMP-AMP (cGAMP). cGAMP then activates stimulator of interferon genes (STING), which triggers a signaling cascade. This cascade ultimately promotes the release of type I interferon (IFN-I), thereby initiating the body’s immune response and DC maturation. This schematic was created by drawing tools from MedPeer (https://www.medpeer.cn)

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