Fig. 1 | Signal Transduction and Targeted Therapy

Fig. 1

From: CDK7-targeted therapy effectively disrupts cell cycle progression and oncogenic signaling in head and neck cancer

Fig. 1

Whole-genome CRISPR screen uncovers genetic essentialities in HNSCC cell lines. a Schematic diagram depicting the experimental workflow of the functional CRISPR/Cas9 KO screen performed in a panel of five different HNSCC cell lines. Created in https://BioRender.com. b Bar graph showing the number of essential genes identified in each HNSCC cell line, categorized by FDR. c Venn diagram illustrating the overlap of essential genes across all five HNSCC cell lines tested (FDR < 0.10). d Pathway analysis of genes commonly essential across all HNSCC cells. e Heat map displaying the essentiality of genes coding for CDKs, based on FDR. f Line graph showing gRNAs counts of CDK7 gene at the initial (day 0) and final time points (day 25) of the screen for each cell line

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