Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Olverembatinib, a multikinase inhibitor that modulates lipid metabolism, in advanced succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 1b study and translational research

Fig. 3

Differences in lipid metabolism among SDH-deficient GISTs. a The Kyoto Encyclopedia of Genes and Genomes (KEGG) (left) and Reactome (right) enrichment bubble plots indicate enrichment of the pathways of the differentially expressed genes in SDH-deficient (n = 8) and non-SDH-deficient (n = 9) GIST tumor tissues. Both plots utilize the top 20 pathways with the smallest q-values for construction; the vertical coordinate lists the pathway; the horizontal coordinate represents the enrichment factor (the number of differentially expressed genes divided by the total number of genes in the pathway); the size indicates the number of differentially expressed genes in the pathway; and the redder the color is, the smaller the q value. b Lipidomic data comparing the lipid abundance of SDH-deficient (n = 7) and non-SDH-deficient GIST (n = 8) tumor tissues. c Gene expression levels related to lipid uptake and lipid synthesis in SDH-deficient (n = 8) and non-SDH-deficient (n = 9) GIST tumor tissues. d Protein expression levels in SDH-deficient (n = 7) and non-SDH-deficient (n = 7) GIST tumor tissues confirmed the results obtained from RNAseq

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