Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Targeted complement inhibition ameliorates the pathological and cognitive outcomes in repetitive mild closed head injury

Fig. 3

Complement inhibition after rmCHI improved cognitive performance. a Experimental design showing the impact and CR2-Crry treatment schedule. b Spatial learning and memory retention were assessed via the Barnes Maze as indicated by the total latency to escape the platform. Statistical analysis for b was carried out via repeated-measures two-way ANOVA with Bonferroni correction for multiple comparisons. Mean +/− SEM. * =p < 0.05; ** =p < 0.01. c Comparison of memory retention on day 8 of the Barnes Maze test was performed by measuring the total latency to escape the platform. Statistical analysis for c was carried out via one-way ANOVA with the Bonferroni correction for multiple comparisons. Mean +/− SEM. * =p < 0.05; ** =p < 0.01. For b, c, the number of replicates was as follows: no injury (n = 9), vehicle (n = 8), and CR2-Crry (n = 10). d Atlas image showing the location of the images captured via confocal microscopy (bregma −1.70 mm) along with representative 40x IHC images showing C3 deposition in vehicle- vs. CR2-Crry-treated animals. e Quantification of C3 deposition in the cortex of vehicle- vs. CR2-Crry-treated animals measured 21 days after the last (12th) impact. Number of replicates: Vehicle (n = 12 images from 3 animals) and CR2-Crry (n = 12 images from 3 animals). Statistical analysis was performed via an unpaired t-test. Mean +/− SEM. **= p < 0.01

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