Fig. 2

Patient CD8 and CD4 immunophenotyping and functional analysis. Flow cytometry analysis was performed on paired peripheral blood mononuclear (PMBC) cells from pre-treatment and post-progression samples from patients M04, M05, M07, M08 and M09. a CD8 and b CD4 plots. Relative expression displayed as net MFI divided by the greatest value per cohort. Patient values that were zero before and after were not included; M02 had only post-treatment PBMCs available. c Co-culture of MUC16^ecto-BITEs and healthy donor PBMC, M02 or M10 PBMC with SKOV3-MUC16^ecto at the indicated E:T ratios. d Co-culture of MUC16^ecto-BITEs and healthy donor PBMC, M02 or M10 PBMC with OVCAR3 at the indicated E:T ratios