Fig. 4

Associations of tumor microenvironment and complement activation with PFS. a Classification of long-survival and short-survival patients according to a PFS cut-off of 5 months. Patients with SD as the best overall response and a PFS of >5 months were defined as SD_Long; patients with SD and a PFS of <5 months were defined as SD_Short; patients with PR and a PFS of >5 months were defined as PR_Long; and patients with PR and a PFS of <5 months were defined as PR_Short. b DEG plots between patients with SD_Long versus SD_Short and between patients with PR_Long versus PR_Short. c SD_Short patients had more infiltration of NK and myeloid cells. d PR_Short patients showed complement activation. Totally, 38 patients were included in these analyses, including 7 patients with PD_Short, 10 with PR_Long, 3 with PR_Short, 8 with SD_Long, and 10 with SD_Short. In the boxplot, the bars represent whiskers, the range of the data. p values are nominal. DEG differentially expressed gene, PFS progression-free survival, PR partial response, SD stable disease, PD progressive response, FC fold change, RSEM RNA-Seq by expectation-maximization, NK natural killer