Fig. 3 | Signal Transduction and Targeted Therapy

Fig. 3

From: Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair

Fig. 3

Invasive intravitreal administration of BiRDS reduces the leakage of laser-induced CNV in a rat model. a Schematic of BiRDs for the laser-induced CNV model. b Representative rat FFA images of CNV at days 7, 14, and 21 (before treatment and on days 7 and 14 after treatment). Red arrows indicate the same lesions across different time points within the same rat. Lesion area (c–e) of the rat CNV treated with BiRDS for 0, 7, or 14 days. f, g The inhibition ratio of rat CNV after treatment for 7 or 14 days. n = 6. Mean ± SD. *p < 0.05

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