Fig. 4 | Signal Transduction and Targeted Therapy

Fig. 4

From: Extraocular delivery of bioswitchable tri-miR-22-loaded tetrahedral DNA nanostructures for intraocular neovascular and neurodegenerative repair

Fig. 4

Ocular penetration and retinal targeting of subconjunctival injection of BiRDS. a Schematic diagram of subconjunctival injection and the study time points. b Panoramic fluorescent flat mounts of mouse eyeballs at 24 h after subconjunctival injection of miR-22 and BiRDS. c Temporal-spatial distribution map of BiRDS-Cy5 in the eye after subconjunctival injection. d Quantitative analysis of fluorescence intensity in different parts of a mouse eyeball (conjunctiva, cornea, iris, sclera, choroid, and retina) at different time points. e Representative fluorescence images of BiRDS penetration across multiple fundus layers at various time points after subconjunctival injection. DAPI (blue) was used to stain the nuclei, and Cy5 (red) was used to stain the BiRDS. INL inner nuclear layer, ONL outer nuclear layer. n = 6. Scale bar: 50 μm

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