Fig. 1

Schematic representation of the innovative peptide design and treatment of a preclinical tumor model. The peptide was designed through characterizations of the bacterial 16S rRNA gene in human tumors, combined with chemical and phylogenetic analysis (a). The aurB peptide enhances radiation sensitivity in tumors through the inhibition of mitochondrial energy production and downregulation of oncogenes, thereby suppressing significant tumor growth and metastasis (b). Created in BioRender, https://BioRender.com