Fig. 1: Mas is upregulated in myeloid cells during MASLD progression. | Signal Transduction and Targeted Therapy

Fig. 1: Mas is upregulated in myeloid cells during MASLD progression.

From: Myeloid Mas drives pyruvate kinase M2-mediated Spi1 lactylation to fuel inflammatory senescence in MASLD

Fig. 1: Mas is upregulated in myeloid cells during MASLD progression.The alternative text for this image may have been generated using AI.

a Schematic of the human MASLD liver section cohort (n = 5 per group) and public datasets (created in https://BioRender.com/avoadxu). b Heatmap of G protein-coupled receptor-related gene expression in human MASLD versus control livers (GEO dataset). c Immunohistochemical staining for Mas in human liver sections (4×, 10×, 20×, scale bar = 200 μm) and quantitative analysis of Mas-positive area. d–g Correlation of MAS1 mRNA levels with serum ALT, AST, TG, and HOMA-IR in the GSE89632 dataset. h–k Correlation of MAS1 mRNA with NAS score and hepatic TNFA, IL1B, and SCD expression in the GSE135251 dataset. l Ridgeline plots showing MAS1 expression across major hepatic cell types in control and MASLD samples. Hepatic Mas1 mRNA (m) and Mas protein (n) levels in mice fed chow or a high-fat diet (HFD; n = 5 per group). o mIHC staining for Mas together with markers for neutrophils (Ly6G), monocytes (CCR2), endothelial cells (CD31), and hepatocytes (HNF4α) in liver sections from chow- and HFD-fed mice (scale bar = 20 μm). Data are shown as the mean ± SD (unpaired Student’s t test, **P < 0.01)

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