Table 2 COAs recommended by the NINDS CDE.

From: Evaluating therapeutic effects of exoskeletons and FES in SCI: integrative review of the literature

COA

Measurement Construct

Scale

PerfO or PRO

Differentiates Compensation

NNIDS CDE for SCI Designation

10 Meter Walk (10MWT)

Gait speed

Ratio

PerfO

No

Supplemental – Highly Recommended

2 min Walk (2MWT)

Endurance

Ratio

PerfO

No

Supplemental – Highly Recommended

6 min Walk (6MWT)

Endurance

Ratio

PerfO

No

Supplemental – Highly Recommended

Spinal Cord Independence Measure (SCIM-III)

Functional Status with activities of daily living and mobility

Ordinal

PerfO and PRO

No

Supplemental – Highly Recommended

Berg Balance Scale (BBS)

Balance

Ordinal

PerfO

No

Supplemental

Capabilities of the Upper Extremity Test *(CUE-T)

Limitations of physical function

Ordinal

PerfO

Yes

Supplemental

Graded Redefined Assessment of Strength Sensibility and Prehension (GRASSP)

Sensorimotor and prehension

Ordinal

PerfO

Yes

Supplemental

Jebsen-Taylor Hand Function Test (JTHFT)

Unilateral hand function

Ratio

PerfO

No

Supplemental

Timed Up and Go (TUG)

Gait function

Ratio

PerfO

No

Supplemental

Walking Index for Spinal Cord Injury I&II (WISCI-I-II)

Assistance during walking

Ordinal

PerfO

No

Supplemental

Canadian Occupational Performance Measure (COPM)

Performance and satisfaction with activities

Ordinal

PRO

No

Supplemental

Spinal Cord Injury Functional Ambulation Inventory (SCI-FAI)

Functional walking ability

Nominal, Ratio, or Ordinal

PRO with 1 PerfO item

Yes

Supplemental

Grasp and Release Test (GRT)

Unilateral hand function

Ratio

PerfO

No

Exploratory

Mini Balance Evaluation Systems Test (Mini BESTest)

Dynamic balance

Ordinal

PerfO

No

Exploratory

Nine Hole Peg Test (9-HPT)

Hand dexterity

Ratio

PerfO

No

Exploratory

Toronto Rehabilitation Institute Hand Function Test (TRI-HFT)

Hand function and grip force

Ordinal, Ratio

PerfO

No

Exploratory

  1. NINDS CDE for SCI Designation: Exploratory: data element requires further validation but may fill current gaps in the CDEs and/or substitute for existing CDE once validation is complete; Supplemental: data element which is commonly collected in clinical research studies but whose relevance depends upon study design or type of research involved; Supplemental – Highly Recommended: data element is essential based on certain conditions or study types in clinical research studies. They have been used and validated in the disease area and are strongly recommended for the disease condition, study type, or design.
  2. BBS berg balance scale, COPM Canadian occupational performance measure, CUE-T capabilities of the upper extremity test, GRASSP graded redefined assessment of strength sensibility and prehension, GRT grasp and release test, JTHFT jebsen-taylor hand function test, Mini BESTest mini balance evaluation systems test, (SCI-FAI) spinal cord injury functional ambulation inventory, SCIM-III spinal cord independence measure, TRI-HFT Toronto rehabilitation institute hand function test, TUG timed up and go, WISCI-I-II walking index for spinal cord injury I&II, 2MWT 2 min walk test, 6MWT 6 min walk test, 9HPT 9 hole peg test, 10MWT 10 meter walk test.
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