Fig. 1
From: Linking the resistome and plasmidome to the microbiome
Hi-C deconvolution workflow. a Formaldehyde induces covalent bonds between DNAs that are close in three-dimensional space (bonds are depicted by black arcs), and therefore within the same cell. b Hi-C library preparation via restriction enzyme digestion (top left), ligation and junction enrichment (bottom left), preparation of the fragment for paired-end sequencing (top right), reads from fragments generated by Hi-C provide linkage information of non-contiguous DNA originated from the same cell (bottom right). c Hi-C links can be used in a graph clustering context to deconvolute contigs into their original cellular groupings, including both chromosomes and plasmids
