Fig. 6: Transition of resistance strategies across the chloramphenicol gradient.
From: Decreased thermal niche breadth as a trade-off of antibiotic resistance
The types of mutations acquired at each timesteps changed as antibiotic levels increased. The most common pathways to resistance at the four timepoints were mutations in the acr efflux pump (T1), ATP synthase genes (T5), outer-membrane proteins (T9), and the mdfA efflux pump (T13).
