Fig. 2: DNA methylation patterns cluster metagenomic contigs into distinct groups.
From: Metagenomic methylation patterns resolve bacterial genomes of unusual size and structural complexity
The methylation status of 32 distinct sequence motifs (m1-m32, columns) is shown on every metagenomic contig (rows, unitig 1 – unitig 169). The value plotted is the percentage of motifs methylated on every contig (square root transformed); bright green color indicates a motif for which every instance on that contig was methylated (100%), and black shows motifs for which no instances were methylated on that contig (0%). When no instances of the sequence motif were observed on a contig, this is indicated as missing data (gray). Rows and columns have been hierarchically clustered using average pairwise linkage based on Euclidean distance. Manually defined methylation groups based on this clustering have been numbered 1–7. A high-resolution version of this figure with legible column and row text is provided in Supplementary Data 2.
