Table 4 Analysis of the flanking regions of dfrB1 to dfrB7 (left panel) and dfrB variants with indices >8 (right panel).
Gene | Origin of read | Superfamily | Putative function | IS | Gene | Origin of read | Superfamily | Putative function | IS |
|---|---|---|---|---|---|---|---|---|---|
dfrB1 | Wi (DE) | DNA_BRE_C | integron integrase | + | dfrB9 | Rw (DE) | − | no significant alignment | − |
dfrB1 | Wi (DE) | DNA_BRE_C | integron integrase | + | dfrB9 | Rs (DE) | − | no significant alignment | − |
dfrB1 | Wi (DE) | DNA_BRE_C | integron integrase | + | dfrB9 | Rs (DE) | − | no significant alignment | − |
dfrB1 | Wi (NZ) | Ybx1 | class D betalactamase | − | dfrB9 | Rs (DE) | − | no significant alignment | − |
dfrB1 | Wi (DE) | DNA_BRE_C | integron integrase | + | dfrB9 | Rs (DE) | − | no significant alignment | − |
dfrB1 | Wi (DE) | DNA_BRE_C | integron integrase | + | dfrB10 | Rs (DE) | CoxL | xanthine dehydrogenase | − |
dfrB1 | Wi (DE) | DNA_BRE_C | integron integrase | + | dfrB10 | Rs (DE) | − | isoprenylcysteine carboxymethyltransferase | − |
dfrB1 | Wi (DE) | N6_acetyl_AAC6 | aminoglycoside acetyltransferase | − | dfrB10 | Rs (DE) | BrnT_toxin | BrnA antitoxin | − |
dfrB1 | Wi (DE) | ANT_3pp_9_crypt | aminoglycoside nucleotidyltransferase | + | dfrB10 | Rs (DE) | CoxL | xanthine dehydrogenase | − |
dfrB2 | We (UK) | EamA | multidrug efflux pump | + | dfrB10 | Rs (UK) | PRK08270 | ribonucleoside triphosphate reductase | − |
dfrB2 | Wi (NZ) | − | hypothetical protein | − | dfrB10 | Rs (NZ) | − | hypothetical protein | − |
dfrB2 | We (UK) | RT_like | reverse transcriptase/maturase | − | dfrB10 | Rs (DE) | Yads | trimeric intracellular cation channel | − |
dfrB3 | We (UK) | DNA_BRE_C | aminoglycoside resistance | + | dfrB10 | Rs (DE) | − | hypothetical protein | − |
dfrB3 | Wi (NZ) | YbxI | class D betalactamase | − | dfrB10 | Rs (DE) | PKc-like | phosphotransferase | − |
dfrB3 | Wi (NZ) | − | hypothetical protein | + | dfrB10 | Rs (DE) | VapI | addiction module antidote | − |
dfrB3 | We (UK) | EamA | multidrug efflux pump | + | dfrB10 | Rs (DE) | VapI | addiction module antidote | − |
dfrB3 | Wi (DE) | DUF1010 | plasmid-encoded protein of unknown function | − | dfrB10 | Rs (DE) | − | BrnA antitoxin | − |
dfrB3 | We (UK) | EamA | multidrug efflux pump | + | dfrB10 | Rw (CN) | − | reverse transcriptase | − |
dfrB3 | We (UK) | EamA | multidrug efflux pump | + | dfrB10 | Rs (DE) | − | isoprenylcysteine carboxymethyltransferase | − |
dfrB3 | We (UK) | EamA | multidrug efflux pump | + | dfrB10 | Rs (DE) | PKc-like | phosphotransferase | − |
dfrB3 | We (UK) | EamA | multidrug efflux pump | + | dfrB10 | Rs (DE) | − | isoprenylcysteine carboxymethyltransferase | − |
dfrB3 | We (UK) | EamA | multidrug efflux pump | + | dfrB10 | Rs (DE) | − | oxidoreductase | − |
dfrB3 | We (UK) | EamA | multidrug efflux pump | + | dfrB10 | Rs (DE) | VapI, ParE_toxin | addiction module antidote | − |
dfrB4 | Rw (CN) | DNA_BRE_C | integron integrase | + | dfrB10 | Rs (DE) | PKc-like | phosphotransferase | − |
dfrB4 | Wi (DE) | EamA | multidrug efflux pump | − | dfrB10 | Rw (NZ) | Ggt | gamma-glutamyltransferase | − |
dfrB4 | We (UK) | − | no significant alignment | − | dfrB10 | Rs (NZ) | Imm6, DUF2486 | deaminase reductase | − |
dfrB4 | We (UK) | DNA_BRE_C | aminoglycoside resistance | + | dfrB10 | We (US) | − | hypothetical protein | − |
dfrB4 | Wi (DE) | DNA_BRE_C | integron integrase | + | dfrB14 | Rs (DE) | HP | histidine phosphatase | − |
dfrB4 | Rw (CN) | LbetaH | acetyltransferase | − | dfrB15 | Rs (DE) | − | hypothetical protein | − |
dfrB5 | Wi (DE) | − | aminoglycoside acetyltransferase | − | dfrB15 | Rs (DE) | SSP160 | N-acetylmuramoyl-L-alanine amidase | − |
dfrB5 | Wi (US) | transpeptidase | ext. spect. class A betalactamase | + | |||||
dfrB7 | Wi (DE) | N6_acetyl_AAC6 | aminoglycoside acetyltransferase | − | |||||
dfrB7 | Wi (DE) | N6_acetyl_AAC6, EamA | aminoglycoside acetyltransferase | − |
