Fig. 4: Overrepresentation analysis of genes with significant fitness effects.
From: Mutualism reduces the severity of gene disruptions in predictable ways across microbial communities
A Dotplot of KEGG pathways significantly overrepresented in the set of genes whose knockout fitness changed significantly as an effect of the presence of E or M (p < 0.05, BH multiple comparisons). Pathways overrepresented are indicated by circles. The plus/minus on the x-axis indicate the direction (relative to monoculture) of the fitness effect on the pathway. The color of the dots indicate the KEGG category of a pathway. Circles with crosses indicate pathways that were investigated further. B Normalized fitness scores for nitrogen metabolism genes in mutualistic (blue) and competitive (red) conditions. Each dot represents the average fitness in a replicate, and the bold horizontal line represents the mean fitness for each gene across replicates. C Normalized fitness scores in representative carbon metabolism genes for acetate (aceA) and galactose (galK) catabolism.
