Fig. 2: eQTLs for Zileuton Response | The Pharmacogenomics Journal

Fig. 2: eQTLs for Zileuton Response

From: The phosphatidylinositide 3-kinase (PI3K) signaling pathway is a determinant of zileuton response in adults with asthma

Fig. 2

. a The Q–Q plot shows the relationship between observed vs. expected (diagonal; gray line) P-values for 735,488 local (red line/dots) and 13,009,811,306 distant (blue line/dots) gene-SNP P values. Jittered boxplots b-e show individual data points (red dots) and medians (±IQR) of log2 mRNA expression values (zileuton:ethanol) (y-axis), stratified by genotype category (“0” = reference allele; “1” = heterozygous variant; “2” = homozygous variant) (x-axis): b Expression of probe 6940358 (gene symbol = SELL) by rs12762462 genotype; c Expression of probe 2760255 (gene symbol = MTF2) by rs10495426 genotype; d Expression of probe 6940358 (gene symbol = SELL) by rs12251868 genotype; e Expression of probe 60452 (gene symbol = GAL) by rs12414020 genotype

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