Fig. 3
From: An optimized prediction framework to assess the functional impact of pharmacogenetic variants
Pharmacogenetic threshold optimization results in substantially higher probabilities to make informed decisions. a The degree of informedness is plotted as a function of threshold score for eight functionality prediction algorithms, six evolutionalry conservation scores and four ensemble scores. The threshold score corresponding to the global maximum of informedness is indicated. ΔI denotes the gain in informedness between using the pharmacogenetically optimized threshold and the conventional threshold provided in the literature. Results are depicted for one of the five folds in our cross-validation analysis. b Averaging the ΔI values of the five folds demonstrates that the increases in informedness due to ADME-specific parameterization differ substantially between algorithms and are stable across folds. As no standard thresholds for PhyloP and PhastCons are provided in the literature, no ΔI values for these conservation scores are shown. Error bars indicate S.D.
