Fig. 4
From: An optimized prediction framework to assess the functional impact of pharmacogenetic variants
The ADME optimized model outperforms conventional methods for the functionality prediction of pharmacogenetic variants. Column plot showing the sensitivity (shades of blue) and specificity (shades of red) of commonly used functionality prediction algorithms, ensemble scores and evolutionary conversation scores as well as of the ADME optimized prediction model presented here. Notably, the ADME optimized model was the only method achieving both sensitivity and specificity of >80% in both training and validation data set. Error bars indicate S.D. across folds
