Table 2 Genetic correlations of antidepressant treatment resistance and stages of resistance in Generation Scotland: Scottish Family Health Study with cognitive and personality traits

From: Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP

 

Treatment resistance

Stages of resistance

P-value

PFDR

rg (s.e.)

N

P-value

PFDR

rg (s.e.)

N

Neuroticism

0.0034

0.0091

0.66

(0.26)

3133

0.0058

0.023

0.51

(0.19)

3133

Extraversion

0.78

0.78

−0.059 (0.22)

3133

0.71

0.71

−0.063 (0.17)

3133

SPQ

0.070

0.11

0.43

(0.26)

1607

0.018

0.036

0.44

(0.20)

1607

MDQ

0.0018

0.0072

0.86

(0.36)

1715

0.010

0.027

0.69

(0.28)

1715

GHQ

1.1 × 10−5

8.8 × 10−5

0.96

(0.26)

3378

0.00014

0.0011

0.71

(0.19)

3378

‘g’

0.32

0.37

−0.16 (0.17)

3349

0.067

0.091

−0.24 (0.133)

3349

Education

0.13

0.17

−0.33 (0.23)

3233

0.40

0.46

−0.15 (0.18)

3233

SIMD

0.063

0.11

−0.22 (013)

3268

0.068

0.091

−0.18 (0.099)

3268

  1. Significant values after multiple testing correction (PFDR < 0.05) are shown in bold
  2. FDR False discovery rate,rP phenotypic correlation,SPQ schizotypal personality questionnaire, MDQ mood disorder questionnaire, GHQ general health questionnaire, SIMD Scottish index of multiple deprivation
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