Table 3 PRS associations with schizophrenia, bipolar disorder and MDD with antidepressant treatment resistance and stages of resistance
Treatment resistance | Stages of resistance | |||||
|---|---|---|---|---|---|---|
Threshold | P-value (PFDR) | Stats | Power at rg 0.5 (& 0.25) | P-value (PFDR) | Stats | Power at rg 0.5 (& 0.25) |
MDD | ||||||
0.01 | 0.35 | β = 0.25 | 0.17 | 0.45 | β = 0.0055 | 0.44 |
(0.54) | R2 = 0.00030 | (0.079) | (0.57) | R2 = 0.00021 | (0.15) | |
0.05 | 0.22 | β = 0.0058 | 0.17 | 0.21 | β = 0.0086 | 0.45 |
(0.46) | R2 = 0.00050 | (0.080) | (0.46) | R2 = 0.00051 | (0.15) | |
0.1 | 0.042 | β = 0.0017 | 0.17 | 0.049 | β = 0.014 | 0.44 |
(0.21) | R2 = 0.0014 | (0.079) | (0.25) | R2 = 0.0013 | (0.15) | |
0.5 | 0.012 | β = 0.012 | 0.16 | 0.015 | β = 0.017 | 0.41 |
(0.20) | R2 = 0.0020 | (0.076) | (0.15) | R2 = 0.0020 | (0.14) | |
1 | 0.030 | β = 0.060 | 0.16 | 0.020 | β = 0.0160 | 0.40 |
(0.20) | R2 = 0.0015 | (0.076) | (0.15) | R2 = 0.0018 | (0.14) | |
SCZ | ||||||
0.01 | 0.027 | β = 0.011 | 1.0 | 0.14 | β = 0.010 | 1.0 |
(0.20) | R2 = 0.0017 | (0.85) | (0.36) | R2 = 0.00074 | (1.0) | |
0.05 | 0.19 | β = 0.0061 | 1.0 | 0.64 | β = 0.0032 | 1.0 |
(0.46) | R2 = 0.00055 | (0.75) | (0.74) | R2 = 7.1 × 10−5 | (1.0) | |
0.1 | 0.68 | β = 0.0019 | 1.0 | 0.87 | β = 0.0011 | 1.0 |
(0.68) | R2 = 5.3 × 10−5 | (0.68) | (0.87) | R2 = 8.1 × 10-6 | (0.99) | |
0.5 | 0.40 | β = 0.0038 | 0.98 | 0.48 | β = 0.0047 | 1.0 |
(0.56) | R2 = 0.00021 | (0.52) | (0.60) | R2 = 0.00015 | (0.95) | |
1 | 0.42 | β = 0.0036 | 0.98 | 0.45 | β = 0.0050 | 1.0 |
(0.56) | R2 = 0.00020 | (0.50) | (0.60) | R2 = 0.00018 | (0.94) | |
BPD | ||||||
0.01 | 0.57 | β = −0.0025 | 0.25 | 0.70 | β = 0.0026 | 0.64 |
(0.65) | R2 = 9.6 × 10−5 | (0.099) | (0.75) | R2 = 4.7 × 10−5 | (0.21) | |
0.05 | 0.59 | β = 0.0024 | 0.26 | 0.45 | β = 0.0050 | 0.65 |
(0.65) | R2 = 8.6 × 10−5 | (0.10) | (0.60) | R2 = 0.00017 | (0.22) | |
0.1 | 0.45 | β = 0.0034 | 0.25 | 0.26 | β = 0.0074 | 0.65 |
(0.56) | R2 = 0.00017 | (0.099) | (0.48) | R2 = 0.00038 | (0.22) | |
0.5 | 0.23 | β = 0.0053 | 0.24 | 0.11 | β = 0.010 | 0.61 |
(0.46) | R2 = 0.00042 | (0.095) | (0.36) | R2 = 0.00074 | (0.20) | |
1 | 0.23 | β = 0.0053 | 0.23 | 0.13 | β = 0.0097 | 0.60 |
(0.46) | R2 = 0.00041 | (0.095) | (0.36) | R2 = 0.00066 | (0.20) | |
