Fig. 2 | The Pharmacogenomics Journal

Fig. 2

From: Towards precision medicine: interrogating the human genome to identify drug pathways associated with potentially functional, population-differentiated polymorphisms

Fig. 2

Drugs associated with population-differentiated genes. a Distribution of the number of drugs that are enriched (Z > 2.58) by pf-pdGenes exhibiting population differentiation patterns across the respective number of population pairs. b Drugs enriched by genes (Z > 2.58) that are population differentiated in all 91 population-pairs examined, sorted by the average Z-score. Each data point corresponds to a specific population pair, with each drug having Z-scores across 91 population-pairs. The dotted horizontal line signifies Z = 2.58, the threshold Z-score for the significant enrichment of pf-pdGenes in the respective population-pair. Red line indicates the average Z-score across the drugs, while the shaded area indicates the minimum and maximum value (the range) of the Z-scores of the respective drug

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