Fig. 3: Global distributions of metabolic phenotypes. | The Pharmacogenomics Journal

Fig. 3: Global distributions of metabolic phenotypes.

From: The genetic landscape of major drug metabolizing cytochrome P450 genes—an updated analysis of population-scale sequencing data

Fig. 3

Frequencies of inferred population-specific metabolic phenotypes are shown for CYP2A6 (a), CYP2B6 (b), CYP2C8 (c), CYP2C9 (d), CYP2C19 (e), CYP2D6 (f), CYP3A4 (g) and CYP3A5 (h). Numbers indicate the fraction of poor metabolizers (PM; dark red), intermediate metabolizers (IM; light red) and rapid metabolizers (RM; green). The fraction of non-normal metabolizers is indicated by the size of circles on the respective world maps. AFR African, EAS East Asian, SAS South Asian, AMR admixed Americans, FIN Finnish, AJ Ashkenazi Jewish, ME Middle Eastern, EUR non-Finnish European.

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