Fig. 1: Atypical antipsychotics commonly decreased slow alpha and higher gamma network oscillations

Full power spectrum expressed as a heat map in fronto–parieto–occipital cortical areas during each 15 min block of the recording session after the administration of a PCP (1.25, 2.5, and 5 mg/kg) in 1 one hemisphere and 2 both hemispheres for, b MK801 (0.16, 0.64, and 2.5 mg/kg), and c amphetamine (0.16, 0.64, and 2.5 mg/kg). As there was no major difference in spectral contents between hemispheres (a2), only right hemisphere locations along the anteroposterior axes were presented in subsequent figures (frontal right “FR”, parietal right “PR”, and occipital right “OR”). Changes in color from cold dark blue to warm red color indicates an order increase in the magnitude of oscillatory power. Curves on the right side indicate the time course changes in the oscillatory activity at alpha1 and gamma2 frequencies during 2 h after the administration of PCP, MK801, and amphetamine. Symmetrical changes in both frequency oscillations were found in both hemispheres see (a2) for PCP; therefore, only right hemisphere was displayed (n = 8 for each condition). Color-coded bars above the curves indicate intervals in which oscillatory activity difference differed from vehicle