Fig. 3

The whole brain functional connectivity patterns of the left NAcc. The whole brain FC map of the early improvers a and non-improvers b. The group differences of whole brain FC patterns of the left NAcc c. The inset box-and-whisker plot indicates the statistical differences of FC between groups. The upper and lower whiskers denote the largest and smallest values, respectively. The early improvers showed higher FC strength between NAcc and vmPFC (MNI coordinates: 6, 57, 0), as well as NAcc and sgACC (MNI coordinates: 3, 33, −21) than in early non-improvers. MNI Montreal Neurological Institute, NAcc nucleus accumbens, sgACC subgenual anterior cingulate cortex, vmPFC ventralmedial prefrontal cortex