Fig. 3 | Translational Psychiatry

Fig. 3

From: Polymorphism in Tmem132d regulates expression and anxiety-related behavior through binding of RNA polymerase II complex

Fig. 3

Adeno-associated virus mediated overexpression of Tmem132d or eGFP in the anterior cingulate cortex of C57BL/6 J mice. Percent time spent in open arm (a), and entries in closed arm (b) on the elevated-plus maze. Percent time spent in light compartment (c), and distance traveled (d) in the light–dark box test. Representative image of animal movement tracks of empty-AAV (e) vs. Tmem132d-AAV (f) injected C57BL/6 J mice. (g) Validation of Tmem132d mRNA expression in the anterior cingulate cortex of empty-AAV vs. Tmem132d-AAV injected C57BL/6 J mice. The data are shown as means ± SEM, numbers in parentheses indicate the group size; *p < 0.05, ***p < 0.001. (h) Representative image showing enhanced green fluorescent protein expression in anterior cingulate cortex (Cg1, Cg2) of C57BL6/J mice

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