Fig. 4
Effect of environmental enrichment (EE) and unpredictable chronic mild stress (UCMS) on HAB and LAB mice, respectively. Percent time spent in open arm (a), and total distance traveled (b) on the elevated-plus maze. Percent time spent in light compartment (c), and total distance traveled (d) in the light–dark box test. e Relative Tmem132d mRNA expression in HAB-SH, HAB-EE, LAB-SH and LAB-UCMS in the anterior cingulate cortex. Data are shown as means ± SEM, numbers in parentheses indicate the group size; # p > 0.05, **p < 0.01, ***p < 0.001. f Chromatin immunoprecipitation assay for POLR2A binding to (rs233264624) A(−310)G locus of HAB-SH/ HAB-EE/ LAB-SH/ and LAB-UCMS. Negative (−ve) and positive (+ve) controls represent occupancy of POLR2A at the active and inactive chromatin marks. The data are shown as means ± SEM with n = 4 for each group. **p < 0.01, ### p < 0.001 (t test)
