Table 3 Total actin, F-actin, G-actin, and phalloidin-binding levels in schizophrenia and comparison subjects

From: Actin polymerization is reduced in the anterior cingulate cortex of elderly patients with schizophrenia

 

Comparison

Schizophrenia

Test statistic

p

ACTraw

2.84 ± 0.68

2.93 ± 0.64

t(28) = 0.38

 

F-actin/ACTraw

0.56 ± 0.05

0.46 ± 0.07

t(28) = 4.39

0.0001

G-actin/ACTraw

0.44 ± 0.05

0.54 ± 0.07

t(28) = 4.39

0.0001

F-actin/G-actin

1.30 ± 0.26

0.89 ± 0.07

t(28) = 4.37

0.0002

ACTnorm

1.88 ± 0.47

1.92 ± 0.43

t(28) = 0.20

 

F-actin/ β-tubulin

1.05 ± 0.25

0.87 ± 0.21

t(28) = 2.11

0.0439

G-actin/ β-tubulin

0.83 ± 0.24

1.04 ± 0.28

t(28) = 2.19

0.0373

Phalloidin (F-actin)

67.95 ± 16.12

47.65 ± 15.15

t(28) = 3.56

0.0014

  1. Total raw actin (ACTraw), β-tubulin-normalized total actin (ACTnorm), and reported ratios are calculated as described in Methods-Data Analysis. Phalloidin (F-actin) is calculated as the average fluorescence value (arbitratry units) for each subject less the average fluorescence of negative control samples containing only phalloidin. Data are reported as means ± standard deviation
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