Table 4 Total actin, F-actin, G-actin, and phalloidin-binding levels in haloperidol and vehicle-treated rats

From: Actin polymerization is reduced in the anterior cingulate cortex of elderly patients with schizophrenia

 

Control

Haloperidol

Test statistic

ACTraw

2.97 ± 0.03

3.01 ± 0.03

t(18) = 0.37

F-actin/ACTraw

0.51 ± 0.01

0.50 ± 0.02

t(18) = 1.22

G-actin/ACTraw

0.49 ± 0.01

0.50 ± 0.02

t(18) = 0.70

F-actin/G-actin

0.99 ± 0.06

0.98 ± 0.04

t(18) = 0.31

ACTnorm

1.97 ± 0.06

1.99 ± 0.06

t(18) = 0.70

F-actin/ β-tubulin

0.98 ± 0.03

1.00 ± 0.04

t(18) = 1.63

G-actin/ β-tubulin

0.99 ± 0.06

0.98 ± 0.04

t(18) = 0.31

Phalloidin (F-actin)

58.27 ± 10.61

58.13 ± 8.93

t(18) = 0.03

  1. Total raw actin (ACTraw), β-tubulin-normalized total actin (ACTnorm), and reported ratios are calculated as described in Methods-Data Analysis. Phalloidin (F-actin) is calculated as the average fluorescence value (arbitratry units) for each subject less the average fluorescence of negative control samples containing only phalloidin. Data are reported as means ± standard deviation; no variables were significantly different between treatment conditions
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