Fig. 2
From: Common basis for orofacial clefting and cortical interneuronopathy
Orofacial and cortical interneuron development occur in spatiotemporal proximity and molecular synchrony. a To identify the lineage of SHH ligand-responding cells, mice with Gli1 promoter-driven and Tamoxifen-inducible Cre recombinase were bred to mice carrying a lacZ reporter with an upstream floxed STOP cassette and administered Tamoxifen at GD8.75. b Whole mount (inset) and sectional staining show reporter-positive cell populations in the medial nasal processes (MNPs) (arrows), and adjacently developing MGEs at GD11.25. c At GD14.0, reporter-positive populations appear along the presumptive tangential migration path of cINs (dotted arrow). d At GD17.0, a population of reporter-positive cells (red) at the deep edge of the cortical plate also express GABA (green). LNP lateral nasal process
