Fig. 4: UCMS-induced changes in synaptic marker densities. | Translational Psychiatry

Fig. 4: UCMS-induced changes in synaptic marker densities.

From: Shifting priorities: highly conserved behavioral and brain network adaptations to chronic stress across species

Fig. 4

Projection images (i.e., three-dimensional composites or z-stack of three z-planes separated by 0.25 µm) of a mouse basolateral amygdala immunolabeled for (a) MAP2, (b) VGLUT1 and (c) PSD95 showing single channels (above black and white) and single channels overlaid with corresponding object masks for each marker (below in green). Scale bar = 5 µm. While UCMS induced no significant changes in (d) MAP2 volume (µm3) per stack or (e) in VGLUT1 puncta per µm3, UCMS increased f the number of PSD95 puncta per µm3. Bar graphs show mean ± s.e.m. *P < 0.05 compared to control group. g PSD95 density in the amygdala showed a trending positive correlation with behavioral emotionality across groups indexed by PC1. Gray bands represent 95% confidence intervals

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