Fig. 2: Conditional effects of AQP4 SNPs on the relationship between sleep duration and brain Aβ burden. | Translational Psychiatry

Fig. 2: Conditional effects of AQP4 SNPs on the relationship between sleep duration and brain Aβ burden.

From: Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden

Fig. 2

Moderating effects of Aquaporin-4 (AQP4) single-nucleotide polymorphisms (SNPs) (A) rs72878776 (dominant model), (B) rs491148 (dominant model), and (C) rs2339214 (recessive model) on the relationship between sleep duration (hours) and brain Aβ burden. M, Minor allele; m, major allele. Dominant genetic model: homozygote for the major allele (mm)) compared to heterozygote/homozygote for the minor allele (mM or MM). Recessive genetic model: homozygote/heterozygote for the major allele (mm or mM) compared to homozygote for the minor allele (MM). Brain Aβ burden is presented as 11C-Pittsburgh compound B (PiB) positron emission tomography (PET) like standardized uptake value ratio (SUVR) and as the Before the Centiloid Kernel Transformation (BeCKeT) scale for florbetapir and flutemetamol studies

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