Table 2 Association of AQP4 SNPs with Pittsburgh Sleep Quality Index sleep parameters

PSQI sleep parameter	SNP Ref	Additive^a		Dominant^a		Recessive^a
PSQI sleep parameter	SNP Ref	Base ^b	Adj ^b	Base ^b	Adj ^b	Base ^b	Adj ^b
PSQI Total	rs71353406	0.130	0.100	0.042	0.045	0.856	0.871
	rs72878776	0.593	0.836	0.647	0.466	0.001 ^c	0.002 ^c
	rs3875089	0.494	0.442	0.940	0.931	0.012	0.021
Sleep disturbances	rs68006382	0.097	0.146	0.034	0.077	0.062	0.902

^aGenetic models: Additive (homozygote for the minor allele (MM) vs. heterozygote for the minor allele (Mm) vs. homozygote for the major allele (mm)); Recessive (homozygote for the minor allele (MM) vs. heterozygote/homozygote for the major allele (Mm/mm)); Dominant (heterozygote/homozygote for the minor allele (Mm or MM) vs. homozygote for the major allele (mm))
^bStatistical models: Base base statistical model including no covariates, Adj Adjusted statistical model (covaries for: age, sex, body mass index (BMI), geriatric depression scale (GDS) and a medical history of CVD). Values that reached nominal significance (p < 0.05, uncorrected) are bolded
^cvalues significant after False Discovery Rate correction (q < 0.05)
Summary of Aquaporin-4 (AQP4) SNPs demonstrating significant associations with sleep parameters. PSQI Pittsburgh Sleep Quality Index Sleep Parameters: PSQI Total, sleep disturbances. SNP Ref, reference single-nucleotide polymorphism marker (rs); AQP4 Aquaporin-4

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