Table 3 Moderation analysis for AQP4 SNPs on sleep latency and sleep duration

From: Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden

	Dominant^a						Recessive^a
	β	s.e.	Sig.	R ²	Sig.	ΔR²	β	s.e.	Sig.	R ²	Sig.	ΔR²
LATENCY
Model summary: rs151246				0.201	<0.001					0.165	<0.001
Age	0.009	0.004	0.023				0.011	0.004	0.012
BMI	0.004	0.006	0.525				0.005	0.006	0.448
CVD risk	−0.015	0.038	0.699				−0.014	0.039	0.731
GDS	−0.007	0.015	0.654				−0.011	0.015	0.469
APOE ε4	0.303	0.056	<0.001				0.310	0.057	<0.001
rs151246	0.117	0.070	0.096				0.064	0.175	0.716
Latency	0.009	0.002	<0.001				0.004	0.002	0.006
INT	−0.009	0.003	0.002			0.039	−0.008	0.007	0.294			0.004
Model summary: rs9951307				0.186	<0.001					0.166	<0.001
Age	0.010	0.004	0.019				0.010	0.004	0.013
BMI	0.003	0.006	0.607				0.004	0.006	0.752
CVD risk	−0.013	0.039	0.741				−0.012	0.039	0.752
GDS	−0.007	0.015	0.658				−0.010	0.015	0.485
APOE ε4	0.312	0.056	<0.001				0.309	0.057	<0.001
rs9951307	0.015	0.070	0.831				0.025	0.123	0.837
Latency	0.008	0.002	0.001				0.004	0.002	0.006
INT	−0.006	0.003	0.048			0.015	−0.005	0.006	0.347			0.004
Model summary: rs71353406				0.180	<0.001					0.163	<0.001
Age	0.010	0.004	0.023				0.010	0.004	0.018
BMI	0.004	0.006	0.556				0.005	0.006	0.401
CVD risk	−0.008	0.039	0.833				−0.012	0.040	0.769
GDS	−0.006	0.015	0.692				−0.009	0.015	0.552
APOE ε4	0.298	0.058	<0.001				0.307	0.058	<0.001
rs71353406	−0.063	0.069	0.362				0.050	0.158	0.754
Latency	0.001	0.002	0.688				0.004	0.002	0.022
INT	0.006	0.003	0.030			0.019	0.003	0.006	0.675			0.001
Model summary: rs3875089				0.184	<0.001					0.165	<0.001
Age	0.010	0.004	0.019				0.011	0.004	0.010
BMI	0.005	0.006	0.400				0.004	0.006	0.458
CVD risk	−0.016	0.039	0.683				−0.017	0.040	0.660
GDS	−0.010	0.015	0.501				−0.012	0.015	0.426
APOE ε4	0.310	0.057	<0.001				0.313	0.058	<0.001
rs3875089	−0.050	0.074	0.497				−0.005	0.416	0.990
Latency	0.002	0.002	0.248				0.004	0.002	0.008
INT	0.007	0.003	0.028			0.019	0.010	0.027	0.706			0.001
Model summary: rs491148				0.185	<0.001					0.193	<0.001
Age	0.010	0.004	0.016				0.012	0.004	0.005
BMI	0.005	0.006	0.360				0.005	0.006	0.393
CVD risk	−0.018	0.039	0.650				−0.017	0.039	0.657
GDS	−0.011	0.015	0.450				−0.011	0.015	0.459
APOE ε4	0.316	0.057	<0.001				0.320	0.057	<0.001
rs491148	−0.035	0.075	0.639				−0.333	0.271	0.220
Latency	0.002	0.002	0.639				0.004	0.001	0.014
INT	0.007	0.003	0.036			0.017	0.035	0.015	0.022			0.020
DURATION
Model summary: rs72878776				0.149	<0.001					0.126	<0.001
Age	0.012	0.004	0.005				0.011	0.004	0.010
BMI	0.005	0.006	0.370				0.004	0.006	0.520
CVD risk	−0.023	0.040	0.565				−0.009	0.040	0.816
GDS	−0.007	0.015	0.662				−0.003	0.015	0.838
APOE ε4	0.289	0.058	<0.001				0.283	0.059	<0.001
rs12968026	0.807	0.352	0.023				0.065	0.715	0.928
Duration	0.026	0.023	0.251				0.005	0.021	0.817
INT	−0.104	0.049	0.034			0.019	−0.010	0.105	0.923			<0.001
Model summary: rs2339214				0.132	<0.001					0.174	<0.001
Age	0.010	0.004	0.018				0.011	0.004	0.009
BMI	0.005	0.006	0.403				0.004	0.006	0.507
CVD risk	−0.011	0.041	0.796				−0.009	0.040	0.819
GDS	−0.005	0.016	0.774				−0.008	0.015	0.595
APOE ε4	0.302	0.059	<0.001				0.307	0.058	<0.001
rs2339214	0.056	0.324	0.864				−0.993	0.329	0.003
Duration	0.014	0.038	0.714				−0.031	0.024	0.197
INT	−0.009	0.045	0.850			<0.001	0.149	0.047	0.002			0.041
Model Summary: rs491148					0.156	<0.001					0.146
Age	0.011	0.004	0.007				0.012	0.004	0.005
BMI	0.005	0.006	0.377				0.004	0.006	0.736
CVD risk	−0.023	0.040	0.565				−0.016	0.040	0.684
GDS	−0.012	0.015	0.419				−0.008	0.015	0.574
APOE ε4	0.317	0.058	<0.001				0.316	0.059	<0.001
rs491148	0.707	0.320	0.028				−0.135	0.662	0.839
Duration	0.030	0.024	0.202				0.005	0.021	0.819
INT	−0.090	0.045	0.045			0.016	0.053	0.097	0.584			0.001

^aGenetic models: Dominant (heterozygote/homozygote for the minor allele (Mm or MM) vs. homozygote for the major allele (mm)), Recessive (homozygote for the minor allele (MM) vs. heterozygote/homozygote for the major allele (Mm/mm)); β coefficient of predictors; Sig p-value; R² coefficient of multiple determination; ΔR² multiple correlation coefficient (R) squared change; APOE Apolipoprotein E ε4 allele carriage (presence/absence); BMI body mass index; CVD risk cardiovascular disease risk; GDS Geriatric Depression Scale; INT Interaction (Sleep Latency/Duration × model summary SNP). Models where the interaction term (INT) resulted in a statistically significant R²-change (p < 0.05) are indicated (bolded)
Model summary statistics for significant Aquaporin-4 (AQP4) reference single-nucleotide polymorphism (SNP) markers (rs)

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Table 3 Moderation analysis for AQP4 SNPs on sleep latency and sleep duration

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