Fig. 1: Pair-wise polygenic association analyses between globally impaired ERP and PRS for each psychiatric or cognitive phenotype for: (a) all subjects and (b) cases with SCZ or BPD. | Translational Psychiatry

Fig. 1: Pair-wise polygenic association analyses between globally impaired ERP and PRS for each psychiatric or cognitive phenotype for: (a) all subjects and (b) cases with SCZ or BPD.

From: Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms

Fig. 1

We derived PRS for schizophrenia, bipolar disorder, college completion, and childhood intelligence from each of the discovery samples with five different P value thresholds (PTs used to select training set SNPs: 0.001, 0.01, 0.05, 0.1, and 0.5; shown with different colors) and apply them to globally impaired ERP in (a) the entire sample and (b) those affected by SCZ or BPD. Each pair is shown on the x-axis and the proportion of variance explained for globally impaired ERP (estimated via Nagelkerke’s pseudo-R²) on the y-axis. *Unadjusted P value < 0.05; **FDR-corrected P value < 0.05 (the total number of testing for multiple comparisons n = 20)

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