Table 1 Demographic and clinical characteristics of globally impaired and non-globally impaired clusters

From: Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms

Phenotype characteristics

All subjects

 

Globally impaired ERP

Non-globally impaired ERP

P value

Diagnosis

  

X2 = 19.11, P = 7.07E−05

SCZ, N (%)

29 (48.3)

107 (33.1)

 

BPD, N (%)

26 (43.3)

96 (29.7)

 

Unaffected, N(%)

5 (8.3)

120 (37.2)

 

Sex

  

X2 = 0.18, P = 0.68

Female, N (%)

30 (50.0)

171 (52.9)

 

Age (years), mean (SD)

43.58 (14.68)

38.41 (13.25)

t-test, P = 0.007

Education (years), mean (SD)

14.58 (2.22)

14.98 (2.27)

t-test, P = 0.22

Current smoker, N (%)

24 (42.1)

77 (24.2)

X2 = 7.86, P = 0.005

MASQ total, mean (SD)

130.53 (37.62)

121.27 (36.70)

t-test, P = 0.11

MLR, P = 0.62

SHPS, mean (SD)

1.84 (2.87)

1.09 (1.92)

t-test, P = 0.02

MLR, P = 0.29

 

Cases with SCZ or BPD

Diagnosis

  

X2 < 0.0001, P = 1.00

SCZ, N (%)

29 (52.7)

107 (52.7)

 

BPD, N (%)

26 (47.3)

96 (47.3)

 

Sex

  

X2 = 2.47, P = 0.12

Female, N (%)

26 (47.3)

120 (59.1)

 

Age (years), mean (SD)

45.02 (14.39)

41.38 (12.68)

t-test, P = 0.07

Education (years), mean (SD)

14.38 (2.2)

14.62 (2.2)

t-test, P = 0.50

Current smoker, N (%)

24 (46.2)

69 (34.3)

X2 = 2.48, P = 0.12

Age of onset (years), mean (SD)

22.35 (8.4)

22.87 (8.3)

t-test, P = 0.70

CPZ equivalent dosage (mg), mean (SD)

286.06 (336.70)

376.62 (508.10)

t-test, P = 0.24

PANSS positive total, mean (SD)

19.88 (7.49)

16.13 (6.98)

t-test, P = 0.007

MLR, P = 0.005

PANSS negative total, mean (SD)

13.18 (7.46)

12.22 (5.64)

t-test, P = 0.42

MLR, P = 0.31

PANSS general total, mean (SD)

32.82 (8.61)

30.28 (9.56)

t-test, P = 0.17

MLR, P = 0.11

MCAS total, mean (SD)

44.54 (8.19)

46.83 (5.71)

t-test, P = 0.09

MLR, P = 0.28

YMRS total, mean (SD)

7.81 (12.22)

8.64 (11.19)

t-test, P = 0.64

MLR, P = 0.91

MASQ total, mean (SD)

134.93 (36.9)

136.49 (38.6)

t-test, P = 0.81

MLR, P = 0.83

SHPS, mean (SD)

2.02 (2.96)

1.65 (2.3)

t-test, P = 0.39

MLR, P = 0.31

  1. X2 is chi-square statistic
  2. t-test is two-sample t-test for equal means
  3. MLR is multivariable linear regression for the association between clinical assessments and globally impaired ERP, adjusting for: (1) age, sex, case–control status, and current smoking status for all subjects; or (2) age, sex, daily chlorpromazine equivalent dose of antipsychotics, and current smoking status for cases with SCZ or BPD
  4. All bold values are significant at P < 0.05
  5. All tests are two sided
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