Table 2 Top sites showing MIA and n-3 induced differential methylation

From: Prenatal immune activation alters the adult neural epigenome but can be partly stabilised by a n-3 polyunsaturated fatty acid diet

  

n-6-SAL vs n-6-POL

n-3-POL vs n-6-POL

 

Gene name

Distance to the gene

q -value

Δmethylation %

q -value

Δmethylation %

CpG sites

Sfi1

16

< 1.10 × 10−16

−26.7 to −6.59

7.18 × 10−14

−23.48 to −5.1

9

Sox17

−62863

< 1.10 × 10−16

10.54 to 18.23

2.58 × 10−13

9.58 to 16.02

6

Pex2

−284438

< 1.10 × 10−16

−17.17 to 14.54

2.60 × 10−11

−10.92 to 10.31

5

Oprk1

−237706

< 1.10 × 10−16

13.94 to 18.02

1.38 × 10−10

10.17 to 13.84

2

Cerk

−9086

< 1.10 × 10−16

−30.08 to −26.79

< 1.10 × 10−16

−23.16

1

Erdr1

−1137.5

< 1.10 × 10−16

−30.08 to −26.79

4.11 × 10−13

−27.73 to −20.44

2

Eya1

196687

< 1.10 × 10−16

16.01 to 24.08

1.30 × 10−11

10.50 to 18.79

2

Filip1l

38241

< 1.10 × 10−16

7.87

3.07 × 10−13

6.6

1

G530011O06Rik

−30472

< 1.10 × 10−16

−34.15 to −32.87

< 1.10 × 10−16

−31.52 to −24.74

2

Gm15386

−272508

< 1.10 × 10−16

9.02 to 13.29

1.36 × 10−13

8.86 to 11.66

2

Pi15

−134875

< 1.10 × 10−16

15.12

< 1.10 × 10−16

12.57

1

Rn45s

2643

< 1.10 × 10−16

−13.6 to 15.71

1.03 × 10−11

−10.53 to −7.62

3

B020004J07Rik

−27301

1.44 × 10−13

−32.83

0.001

−19.01

1

3110070M22Rik

−120

2.03 × 10−13

−9.74 to 9.93

1.03 × 10−9

−7.79 to 4.61

3

Zbtb24

−12896

1.49 × 10−11

−30.62

0.028

−14.75

1

Gm10377

82454

9.70 × 10−10

26.22

5.86 × 10−4

18.25

1

Gm5415

−472527

1.50 × 10−9

9.34

6.09 × 10−7

8.23

1

4930515L03Rik

−71170

2.40 × 10−9

28.79

0.166

10.06

1

1700030C10Rik

582097

3.59 × 10−9

−11.27

0.001

−7.67

1

2900097C17Rik

29994

4.24 × 10−9

−28.16

0.003

−18.63

1

Itgbl1

11323

3.08 × 10−8

26.72

0.022

15.49

1

Plcd3

17139

6.12 × 10−8

−29.14

0.004

−21.17

1

Gm17026

54903

1.06 × 10−7

23.73

0.002

17.17

1

Rpia

703669

1.24 × 10−7

22.35

1.81 × 10−4

17.75

1

Mir684-1

−41569

1.56 × 10−7

−26.42

0.001

−20.93

1

9330188P03Rik

196

2.15 × 10−7

−24.76

0.152

−10.96

1

Zp3r

28668

4.36 × 10−7

27.79

0.025

18.48

1

Ppp1r15b

40280

7.88 × 10−7

−27.33

0.002

−19.61

1

  1. List of top differentially methylated genes. n-6-SAL vs n-6-POL comparison lists the MIA effect, n-3-POL vs n-6-POL comparison lists the n-3 effect. Average distance from the CpG sites to the nearest gene, q-value—BH corrected p-value, Δmethylation—difference in methylation in percentages listed as a range, number of differentially methylated CpG sites are listed in the gene. The lowest q-value among the differentially methylated CpG sites is listed
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