Table 3 Exploratory analysis of association of C4BL copy number repeats with MPL metabolite levels among young adult-onset schizophrenia (YASZ) and matched healthy controls, and a combined sample of AOSZ + HC
GPC + GPE↑ | GPC + GPE↓ | PC + PE↑ | PC + PE↓ | |
|---|---|---|---|---|
Sample 1: Young adult-onset schizophrenia and age-matched HC | ||||
YASZ + HC | L. Inferior Parietal Lobule (AIC = −32.32; β = 0.32, t = 3.43, p = 0.002) (d = 0.56) | – | R. Vent Hippocampus (AIC = −17.92; β = 0.25, t = 2.31, p = 0.027) (d = 0.38) | R. Dorsolateral Prefrontal Cortex (AIC = −19.50; β = −0.38, t = 2.65, p = 0.012); (d = 0.44) |
YASZ | Cerebellar Vermis (AIC = −9.64; β = 0.42, t = 2.69, p = 0.02) (d = 0.69) | – | L. Inferior Parietal Lobule (AIC = −13.44; β = 0.91, t = 3.37, p = 0.006) (d = 0.87) | – |
L. Superior Temporal Gyrus (AIC = −10.89; β = 0.48, t = 2.60, p = 0.025) (d = 0.67) | – | L. Orbitofrontal Cortex (AIC = −10.25; β = 0.18, t = 2.74, p = 0.019) (d = 0.71) | – | |
HC | L. Superior Parietal Lobule (AIC = −18.04; β = 1.86, t = 37.20, p < 0.001) (d = 7.93) | L. Superior Temporal Gyrus (AIC = −30.15; β = −1.05, t = 31.78, p < 0.001) (d = 6.77) | Posterior Cingulate Cortex (AIC = −12.43; β = 0.55, t = 3.45, p = 0.003) (d = 0.73) | R. Dorsolateral Prefrontal Cortex (AIC = −10.78; β = −0.38, t = 3.50, p = 0.003) (d = 0.75) |
Posterior Cingulate Cortex (AIC = −15.18; β = 1.42, t = 31.15, p < 0.001) (d = 6.61) | L. Dorsolateral Prefrontal Cortex (AIC = −15.18; β = −0.74, t = 25.72, p < = 0.001) (d = 5.41) | L. Hippocampus (AIC = −18.13; β = 0.37, t = 2.37, p = 0.031) (d = 0.50) | R. Caudate (AIC = −15.36; β = −0.71, t = 3.40, p = 0.004) (d = 0.73) | |
L. Caudate (AIC = −41.64; β = 0.45, t = 12.31, p < 0.001) (d = 2.61) | L. Dorsal Hippocampus (AIC = −46.70; β = −0.65, t = 13.34, p < 0.001) (d = 2.87) | |||
L. Ventral Hippocampus (AIC = −74.51; β = 0.08, t = 4.74, p = 0.001) (d = 1.00) | R. Anterior Cingulate Cortex (AIC = −37.77; β = −0.26, t = 12.57, p < 0.001) (d = 2.63) | |||
Sample 2: Adolescent-onset schizophrenia and age-matched HC | ||||
AOSZ + HC | R. Caudate AIC = −34.93; (β = 0.16, t = 10.07, p < 0.001) (d = 1.95) | R. Thalamus (AIC = −37.35; β = −0.14, t = 6.68, p < 0.001) (d = 1.26) | – | – |
R. Hippocampus (AIC = − 34.92; β = 0.16, t = 8.07, p < 0.001) (d = 1.56) | R. Anterior Cingulate Cortex (AIC = −42.36; β = −0.03, t = 5.27, p < 0.001) (d = 1.09) | – | – | |
R. Dorsolateral Prefrontal Cortex (AIC = −49.12; β = 0.03, t = 6.21, p < 0.001) (d = 1.19) | L. Dorsolateral Prefrontal Cortex (AIC = −41.64; β = −0.03, t = 2.18, p = 0.046) (d = 0.44) | – | – | |
Ventral Prefrontal Cortex (AIC = −46.07; β = 0.04, t = 5.50, p < 0.001) (d = 1.03) | – | – | – | |
L. Orbitofrontal Cortex (AIC = −34.93; β = 0.03, t = 5.34, p < 0.001) (d = 1.01) | – | – | – | |
L. Hippocampus (AIC = −34.93; β = 0.09, t = 2.95, p = 0.011) (d = 0.56) | – | – | – | |
