Table 2 Characteristics and OR for women with PCOS in the CPRD
From: Polycystic ovary syndrome and autism: A test of the prenatal sex steroid theory
Characteristics | PCOS phenotypea | Controls | Controls–PCOS phenotype | |||
|---|---|---|---|---|---|---|
Count | % Total | Count | % Total | Unadjusted OR (95% CI) | Adjusted OR (95% CI)b | |
Total | 26,263 | – | 130,717 | – | – | – |
Mean age | 35.5 ± 8.5 | – | 34.5 ± 8.5 | – | – | – |
Mean age at PCOS diagnosis | 27.6 ± 7.5 | – | – | – | – | – |
Mean age at ASC diagnosis | 16.2 ± 8.9 | – | 18.1 ± 11.8 | – | – | – |
ASC | ||||||
Autism | 25 | 0.10 | 62 | 0.05 | 2.01 (1.26–3.20)* | – |
Asperger’s | 19 | 0.07 | 46 | 0.04 | 2.06 (1.21–3.51)* | – |
PDD-NOS | 1 | 0.00 | 7 | 0.00 | – | – |
Total | 45 | 0.17 | 115 | 0.09 | 1.94 (1.37–2.76)** | 1.41 (0.96–2.07)^ |
Other psychiatric conditions | ||||||
Depression | 8700 | 33.1 | 22,247 | 17.0 | 2.53 (2.45–2.61)** | 2.16 (2.09–2.24)** |
Anxiety | 5608 | 21.4 | 13,825 | 10.6 | 2.37 (2.28–2.45)** | 1.76 (1.69–1.84)** |
Schizophrenia | 233 | 0.89 | 696 | 0.53 | 1.67 (1.44–1.94)** | 1.11 (0.93–1.32) |
Metabolic conditions | ||||||
Diabetes mellitus | 898 | 3.4 | 1218 | 0.9 | 3.87 (3.54–4.23)** | – |
Obesity | 4904 | 18.7 | 3976 | 3.0 | 7.80 (7.44–8.18)** | – |
