Table 1 The key data of all studies targeting the dopamine transporter

From: Striatal dopaminergic alterations in Tourette’s syndrome: a meta-analysis based on 16 PET and SPECT neuroimaging studies

Year

First author

Tracer (target)

Method

TS patients

Healthy controls

Scores

Drug free

2000

Müller-Vahl

ß-CIT (DAT)

SPECT

6

9

STSS 3,3 (6)

5 month

2001

Stamenkovic

ß-CIT (DAT)

SPECT

15

10

YGTTS 67,65 (100)

Drug-naïve

2004

Serra-Mestres

FP-CIT (DAT)

SPECT

10

10

YGTTSS 47,6 (100)

Drug-naïve

2007

Yeh

TRODAT (DAT)

SPECT

8

8

YGTTSS 25 (100)

Drug-naïve

2008

Hwang

TRODAT (DAT)

SPECT

10

15

MRVRS 11,7 (20)

3 month

2008

Wong

C11 WIN (DAT)

PET

11

5

YGTSS 50,27 (100)

6 month

2009

Albin

MP (DAT)

PET

33

28

YGTSS 37 (100)

3 month

2010

Liu

TRODAT (DAT)

SPECT

18

8

YGTTSS 39,17 (100)

Drug naive

SUM

   

111

93

  
  1. Method: positron emission tomography (PET), single-photon emission computed tomography (SPECT). Scores: Yale Global Tic Severity Scale (YGTSS); Shapiro Tourette Syndrome Severity Scale (Shapiro STSS); Modified Rush Videotape Rating Scale (MRVRS). Drug free: drug-free interval before scan