Fig. 2 | Translational Psychiatry

Fig. 2

From: Cortical substrates of cue-reactivity in multiple substance dependent populations: transdiagnostic relevance of the medial prefrontal cortex

Fig. 2

Drug class specific topography. In cocaine users (n = 55; red), cocaine cues led to significantly more BOLD signal than neutral cues in 3 clusters: (1) Left Brodmann 6 (−39,5,29; 1332, p < 0.000), (2) Right Brodmann 44 (45,8,29; 1057; p < 0.000), (3) Left Brodmann 10, ventral MPFC (−6,56, −10; 165, p = 0.039). In alcohol users (n = 53; blue) alcohol cues led to a significant increase in BOLD signal relative to neutral cues in 1 cluster: Brodmann 24/32, anterior cingulate (1,32,8; 300; p = 0.008) which extended through the MPFC. In cigarette smokers (n = 48; green), cigarette cues also led to an increase in BOLD signal in 1 cluster: (1) Brodmann 24/32, anterior cingulate (−1, 36, 10; 210; p = 0.048) which extended through the MPFC. The areas not included in the data analysis are shown with stippled boxes

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