Table 3 PRS association with clinical variables of risperidone treatment response

From: Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort

Clinical variables (follow-up - baseline)

N

B

p-value

Five-factor model21

ΔPANSS negative

53

−71.6

0.5948

ΔPANSS positive

53

−74.5

0.6824

ΔPANSS disorganization

53

−35.3

0.8493

ΔPANSS depression/anxiety

52

222.7

0.1173

aΔPANSS excitement

53

473.5

0.0034

bΔCDSS

 

49

717.2

0.0006

  1. Delta was calculated subtracting the measures of follow-up minus the baseline
  2. aSignificant p-values without Bonferroni correction
  3. bSignificant p-values with Bonferroni correction
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