Table 4 Association between the statistically significant clinical variables with PRS splitting the FEP patients into FEP subtypes according to the follow-up diagnosis

From: Polygenic risk score analyses of symptoms and treatment response in an antipsychotic-naive first episode of psychosis cohort

Subtype

Clinical variable

Timepoint

N

B

p-value

Schizophreniform

a−GAF

Baseline

9

−1449.1

0.00013

bCDSS

Baseline

9

2660.0

0.03594

CDSS

Follow-up

10

−2323.7

0.20033

aPANSS excitement

Baseline

11

1393.3

0.00009

PANSS depression/anxiety

Follow-up

10

−622.3

0.15126

bΔPANSS excitement

Baseline - follow-up

11

877.8

0.02002

ΔCDSS

Baseline - follow-up

9

497.4

0.30954

Schizophrenia only

−GAF

Baseline

27

300.3

0.21538

bCDSS

Baseline

29

1746.1

0.00217

aCDSS

Follow-up

27

−3739.3

0.00009

PANSS excitement

Baseline

29

206.5

0.39645

aPANSS depression/anxiety

Follow-up

29

−1286.2

0.00002

ΔPANSS excitement

Baseline - follow-up

29

324.9

0.19858

aΔCDSS

Baseline - follow-up

27

1358.7

0.00002

  1. aSignificant p-values with Bonferroni correction
  2. bSignificant p-values without Bonferroni correction