Table 2 Association of polygenic risk scores across variously defined bipolar strata
Est (95% CI) | p value | Nagelkerke’s R 2 | |
|---|---|---|---|
Comparison to 778 controls | |||
BD case (N = 958) | 0.33 (0.24, 0.42) | 2.0e−12 | 0.038 |
Stratified by type | |||
BD type I (N = 696) | 0.35 (0.25, 0.45) | 2.8e−12 | 0.044 |
BD type II (N = 261) | 0.26 (0.13, 0.40) | 9.8e−05 | 0.021 |
Stratified by psychosis subtype | |||
Manic psychosis (N = 333) | 0.46 (0.34, 0.58) | 2.1e−13 | 0.065 |
Depressive psychosis (N = 64) | 0.20 (−0.04, 0.44) | 0.103 | 0.007 |
No psychosis (N = 547) | 0.26 (0.16, 0.37) | 7.6e−07 | 0.025 |
Within-case comparisons | |||
Manic psychosis vs. no psychosis | 0.20 (0.07, 0.32) | 0.003 | 0.014 |
Depressive psychosis vs. no psychosis | −0.06 (−0.31, 0.18) | 0.611 | 0.001 |
Manic psychosis vs. depressive psychosis | 0.26 (0.01, 0.51) | 0.043 | 0.016 |
Split by BD type | |||
BD-I vs. BD-II | 0.09 (−0.05, 0.22) | 0.209 | 0.003 |
Manic psych vs. BD-I-no psych (N = 312) | 0.20 (0.05, 0.34) | 0.007 | 0.015 |
BD-I-dep psych (N = 42) vs. BD-I-no psych | −0.11 (−0.41, 0.19) | 0.481 | 0.005 |
Manic psychosis vs. BD-I-dep psychosis | 0.31 (0.01, 0.61) | 0.045 | 0.021 |
Manic psych vs. BD-II-no psych (N = 235) | 0.19 (0.03, 0.35) | 0.017 | 0.014 |
BD-I-no psych vs. BD-II-no psych | −0.01 (−0.17, 0.15) | 0.922 | 6 × 10−5 |
