Fig. 2: Group effects in primary and secondary region of interest (ROI) analysis of activation associated with novelty processing (novel oddballs vs. neutral oddballs).

a Primary ROI (colour coding pink): SN/VTA, maximal difference at x = 0, y = −20, z = −6. Secondary ROI (colour coding green), striatum, two clusters maximal difference at x = 8, y = −2, z = 14 and x = −8, y = −2, z = 12 (p < 0.05 FWE corrected). b Bar chart shows the mean contrast (COPEs, FSL) values to group, extracted from significant clusters determined by FSL randomise ANOVA results of primary and secondary ROI analysis. Multiple significant clusters are combined. Error bars show ±1 SE