Fig. 3: Group effects in primary and secondary region of interest (ROI) analysis of activation associated with negative emotional salience processing (emotional oddballs vs. neutral oddballs).

a Primary ROI (colour coding pink): SN/VTA, four clusters maximal differences at x = −12, y = −16, z = −6; x = 0, y = −20 z = −4; x = −10, y = −22, z = −20; and x = −12, y = −26, z = −20, and amygdala maximal differences at x = 22, y = 0, z = −14. Secondary ROI (colour coding green), striatum, four clusters, maximal differences at x = 12, y = 14, z = 12; x = −10, y = −6, z = −16; x = −12, y = 6, z = −14 and x = −14, y = 22, z = −2 (p < 0.05 FWE corrected). b Bar chart shows the mean contrast (COPEs, FSL) values to group, extracted from significant clusters determined by FSL randomise ANOVA results of primary and secondary ROI analysis. Multiple significant clusters are combined. Error bars show ±1 SE