Fig. 5: Enrichment of MAPT p.R406W dysregulated genes in genetic risk for FTD. | Translational Psychiatry

Fig. 5: Enrichment of MAPT p.R406W dysregulated genes in genetic risk for FTD.

From: Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSP

Fig. 5: Enrichment of MAPT p.R406W dysregulated genes in genetic risk for FTD.The alternative text for this image may have been generated using AI.

To determine whether the 61 verified differentially expressed genes in MAPT p.R406W carriers were enriched for FTD risk, i-GSEA4GWAS was employed for enrichment analysis of FTD risk. a Gene-based Manhattan plot of the enrichment analysis of the genetic association signals from FTD summary statistics for the 61 verified differentially expressed genes. b Comparative QQ plot of the genetic association signals from FTD summary statistics between all genes and the 61 verified differentially expressed genes

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